Apr 30, 2015 · The common approach for protein subfamily classification relies on grouping protein sequences according to their degree of similarity.
Apr 30, 2015 · The common approach for protein subfamily classification relies on grouping protein sequences according to their degree of similarity.
Jul 6, 2024 · However, there is no single sequence similarity threshold that serves to accurately group proteins into isofunctional groups.
Since all proteins within a superfamily share a common ancestor, it is hypothesize that functional diversity within superfamilies has arisen through a ...
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Mar 12, 2024 · Coevolutionary signals are searched separately within these clades, and are only subsequently integrated using machine learning techniques. We ...
In other words, functionally related residues in a protein will often coevolve. The extent of this coevolution can be quantified from protein sequence ...
Jul 25, 2017 · Co-evolution techniques were originally conceived to assist in protein structure prediction by inferring pairs of residues that share spatial proximity.
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Oct 20, 2015 · In this paper we combine coevolutionary data and molecular dynamics simulations to study protein conformational heterogeneity.
Jan 17, 2018 · Pairwise coevolutionary models capture the collective residue variability across homologous proteins even for quantities which are not imposed by the inference ...
Sep 6, 2023 · Why these algorithms predict a single fold is unclear, but all of them infer protein structure from coevolved amino acid pairs. Here, we ...