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Cell death

Waste management and cell death in T cells

Nature Cell Biology (2024)Cite this article

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After being activated, T lymphocytes must consume fuel for energy and biomaterials to sustain rapid proliferation and differentiation. As a consequence, waste is generated that must be managed. A new study now explores how activated CD8+ effector T cells handle ammonia, and how this impacts the survival and function of these cells.

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Fig. 1: Ammonia and CD8+ Teff cells.

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Authors and Affiliations

  1. Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Douglas R. Green

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  1. Douglas R. Green
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Correspondence to Douglas R. Green.

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Competing interests

D.R.G. receives funding from Amgen and consults for SAHA Therapeutics and Mycos Therapeutics.

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Green, D.R. Waste management and cell death in T cells. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01538-0

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