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This was done in three basic steps. Firstly, a multiple alignment of domains was generated for each type of fold studied. Secondly, the alignment was used to ...
Automatic determination of protein fold signatures from structural superpositions. A.P. Cootes1,3, S.H. Muggleton2,4, R.B. Greaves2 and M.J. Sternberg1,3 ...
Such constraints might be considered "signatures" of a given fold and their identification would be useful for the classification of protein structure.
Protein topology diagrams are 2D representations of protein structure that are particularly useful in understanding and analysing complex protein folds.
Automatic determination of protein fold signatures from structural superpositions. A.P. Cootes1,3, S.H. Muggleton2,4, R.B. Greaves2 and M.J. Sternberg1,3 ...
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The work showed that signatures of protein folds exist, about half of rules discovered automatically coincide with the level of fold in the SCOP classification.
Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a ...
Here, we demonstrate a machine-learning strategy that automatically determines the structural principles describing 45 folds. The rules learnt were shown to be ...
There are constraints on a protein sequence/structure for it to adopt a particular fold. These constraints could be either a local signature invol-.
Apr 2, 2004 · They also enable systematic survey and analysis of various structural properties for performing fold predictions. The database may be ...