Here, we introduce clone to mutation (CloMu), a flexible and low-parameter tree generative model of cancer evolution. CloMu uses a two-layer neural network ...

Jan 23, 2013 · Since the advent of next–generation sequencing of cancer genomes, mathematical investigations of cancer dynamics have expanded dramatically.

The clonal evolution model of cancer is an alternative model for the organizational structure of tumors initially described by Peter Nowell in 1976 [17].

Cancer is a subclonal evolutionary process and is governed by the dynamic interplay of mutation, stochastic drift, and selection (1–3). Although most mutations ...

We developed a clonal deconvolution method, which incorporates explicitly the temporal spacing of longitudinally sampled tumours.

ClonEvol automates the generation of multiple widely used visualizations for reconstructing and interpreting clonal evolution.

Feb 22, 2023 · Functional characterization of the cancer clones can shed light on the evolutionary mechanisms driving cancer's proliferation and relapse ...

The advent of next-generation sequencing has enabled more powerful analysis of tumor evolution and has improved our understanding of tumor initiation and ...

Nov 1, 2013 · These bioinformatics tools have been critical in deducing the clonal history of individual tumors using sequencing data from tumor samples with ...

We review recent approaches to modeling the evolution of cancer, including population dynamics models of tumor initiation and progression.