In the context of the gradual development of artificial intelligence in health care, the clinical decision support systems (CDSS) play an increasing crucial role in improving the quality of the therapeutic and diagnostic efficiency in health care. The fuzzy logic (FL) provides an effective means for dealing with uncertainties in the health decision‐making process; therefore, FL‐based CDSS becomes a very powerful tool for data and knowledge management, being able to think like an expert clinician. This work proposes an FL‐based CDSS for the evaluation of renal function in posttransplant patients.

Based on the data provided by the Department of Nephrology of the University Hospital Federico II of Naples, a statistical sample is selected according to appropriate inclusion criteria. Four fuzzy inference systems are implemented monitoring the renal function by the level of proteinuria and the glomerular filtration rate (GFR).

The systems show an accuracy of more than 90% and the outputs are provided through easy to read graphics, so that physicians can intuitively monitor the patient's clinical status, with the objective to improve drugs dosage and reduce medication errors.

We propose that the CDSSs for the assessment and follow‐up of kidney‐transplanted patients built in this study are applicable to clinical practice.