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Search Results (233)

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Keywords = Lv’s distribution

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20 pages, 5342 KiB  
Article
Optimal EV Charging and PV Siting in Prosumers towards Loss Reduction and Voltage Profile Improvement in Distribution Networks
by Christina V. Grammenou, Magdalini Dragatsika and Aggelos S. Bouhouras
World Electr. Veh. J. 2024, 15(10), 462; https://doi.org/10.3390/wevj15100462 - 11 Oct 2024
Viewed by 545
Abstract
In this paper, the problem of simultaneous charging of Electrical Vehicles (EVs) in distribution networks (DNs) is examined in order to depict congestion issues, increased power losses, and voltage constraint violations. To this end, this paper proposes an optimal EV charging schedule in [...] Read more.
In this paper, the problem of simultaneous charging of Electrical Vehicles (EVs) in distribution networks (DNs) is examined in order to depict congestion issues, increased power losses, and voltage constraint violations. To this end, this paper proposes an optimal EV charging schedule in order to allocate the charging of EVs in non-overlapping time slots, aiming to avoid overloading conditions that could stress the DN operation. The problem is structured as a linear optimization problem in GAMS, and the linear Distflow is utilized for the power flow analysis required. The proposed approach is compared to the one where EV charging is not optimally scheduled and each EV is expected to start charging upon its arrival at the residential charging spot. Moreover, the analysis is extended to examine the optimal siting of small-sized residential Photovoltaic (PV) systems in order to provide further relief to the DN. A mixed-integer quadratic optimization model was formed to integrate the PV siting into the optimization problem as an additional optimization variable and is compared to a heuristic-based approach for determining the sites for PV installation. The proposed methodology has been applied in a typical low-voltage (LV) DN as a case study, including real power demand data for the residences and technical characteristics for the EVs. The results indicate that both the DN power losses and the voltage profile are further improved in regard to the heuristic-based approach, and the simultaneously scheduled penetration of EVs and PVs could yield up to a 66.3% power loss reduction. Full article
(This article belongs to the Special Issue Data Exchange between Vehicle and Power System for Optimal Charging)
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29 pages, 8205 KiB  
Article
A Robust Translational Motion Compensation Method for Moving Target ISAR Imaging Based on Phase Difference-Lv’s Distribution and Auto-Cross-Correlation Algorithm
by Can Liu, Yunhua Luo and Zhongjun Yu
Remote Sens. 2024, 16(19), 3554; https://doi.org/10.3390/rs16193554 - 24 Sep 2024
Viewed by 549
Abstract
Translational motion compensation constitutes a pivotal and essential procedure in inverse synthetic aperture radar (ISAR) imaging. Many researchers have previously proposed their methods to address this requirement. However, conventional methods may struggle to produce satisfactory results when dealing with non-stationary moving targets or [...] Read more.
Translational motion compensation constitutes a pivotal and essential procedure in inverse synthetic aperture radar (ISAR) imaging. Many researchers have previously proposed their methods to address this requirement. However, conventional methods may struggle to produce satisfactory results when dealing with non-stationary moving targets or operating under conditions of low signal-to-noise ratios (SNR). Aiming at this challenge, this article proposes a parametric non-search method that contains two main stages. The radar echoes can be modeled as polynomial phase signals (PPS). In the initial stage, the energy of the received two-dimensional signal is coherently integrated into a peak point by leveraging phase difference (PD) and Lv’s distribution (LVD), from which the high-order polynomial coefficients can be obtained accurately. The estimation of the first-order coefficients is conducted during the second stage. The auto-cross-correlation function for range profiles is introduced to enhance the accuracy and robustness of estimation. Subsequently, a novel mathematical model for velocity estimation is proposed, and its least squares solution is derived. Through this model, a sub-resolution solution can be obtained without requiring interpolation. By employing all the estimated polynomial coefficients, the non-stationary motion of the target can be fully compensated, yielding the acquisition of a finely focused image. Finally, the experimental findings validate the superiority and robustness of the proposed method in comparison to state-of-the-art approaches. Full article
(This article belongs to the Topic Radar Signal and Data Processing with Applications)
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18 pages, 4644 KiB  
Article
Optimization Strategy for an Outage Sequence in Medium- and Low-Voltage Distribution Networks Considering the Importance of Users
by Wei Li, Jingzhe Wang, Hao Bai, Yongqian Yan, Min Xu, Yipeng Liu, Hao Wang, Wei Huang and Chunyan Li
Appl. Sci. 2024, 14(18), 8386; https://doi.org/10.3390/app14188386 - 18 Sep 2024
Viewed by 846
Abstract
With the rapid development of distribution networks and increasing demand for electricity, the pressure of power supply for medium- and low-voltage distribution networks (M&LVDNs) is increasingly significant, especially considering the large scale of customers at the low-voltage (LV) level. In this paper, an [...] Read more.
With the rapid development of distribution networks and increasing demand for electricity, the pressure of power supply for medium- and low-voltage distribution networks (M&LVDNs) is increasingly significant, especially considering the large scale of customers at the low-voltage (LV) level. In this paper, an outage sequence optimization method for low-voltage distribution networks (LVDNs) that considers the importance of users is proposed. The method aims to develop an optimal outage sequence strategy for LV customers in case of medium-voltage (MV) failure events. First, a multi-dimensional importance indicator system for LV users is constructed, and the customers are ranked using a modified Analytic Hierarchy Process–Entropy Weight (AHP-EW) method to determine their priorities during outages. Then, an elastic net regression-based method is used to identify the topology of the LV network. Finally, an outage sequence optimization model based on the user importance is proposed to reduce the load-shedding level. Extensive case studies are conducted in the modified LV distribution network. The results show that the proposed method results in fewer outage losses throughout the restoration periods than traditional methods and effectively improves the reliability of the power supply to LV users. Full article
(This article belongs to the Section Electrical, Electronics and Communications Engineering)
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18 pages, 1264 KiB  
Article
Chernobyl Disaster Optimizer-Based Optimal Integration of Hybrid Photovoltaic Systems and Network Reconfiguration for Reliable and Quality Power Supply to Nuclear Research Reactors
by Sobha Rani Penubarthi, Radha Rani Korrapati, Varaprasad Janamala, Chaitanya Nimmagadda, Arigela Satya Veerendra and Srividya Ravindrakumar
Modelling 2024, 5(3), 1268-1285; https://doi.org/10.3390/modelling5030065 - 13 Sep 2024
Viewed by 677
Abstract
In view of the complexity and importance of nuclear research reactor (NRR) installations, it is imperative to uphold high standards of reliability and quality in the electricity being supplied to them. In this paper, the performance of low-voltage (LV) distribution feeders integrated with [...] Read more.
In view of the complexity and importance of nuclear research reactor (NRR) installations, it is imperative to uphold high standards of reliability and quality in the electricity being supplied to them. In this paper, the performance of low-voltage (LV) distribution feeders integrated with NRRs is improved in terms of reduced distribution loss, improved voltage profile, and reduced greenhouse gas (GHG) emissions by determining the optimal location and size of photovoltaic (PV) systems. In the second stage, the power quality of the feeder is optimized by reducing the total harmonic distortion (THD) by optimally allocating D-STATCOM units. In the third and fourth stages, the reliability and resilience aspects of the feeder are optimized using optimal network reconfiguration (ONR) and by integrating an energy storage system (ESS). To solve the non-linear complex optimization problems at all these stages, an efficient meta-heuristic Chernobyl disaster optimizer (CDO) is proposed. Simulations are performed on a modified IEEE 33-bus feeder considering the non-linear characteristics of NRRs, variability of the feeder loading profile, and PV variability. The study reveals that the proposed methodology can significantly improve the service requirements of NRRs for attaining sustainable research activities. Full article
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22 pages, 10623 KiB  
Article
Analysis of Underground Distribution System Models for Secondary Substations
by Boohyun Shin, Hyeseon Lee and Sungyun Choi
Energies 2024, 17(17), 4345; https://doi.org/10.3390/en17174345 - 30 Aug 2024
Viewed by 462
Abstract
In Korea, the demand for complete underground installation of power distribution equipment installed on roads and green areas is increasing. In addition, KEPCO is making efforts to build a more reliable system for the underground distribution system. To meet these needs, this paper [...] Read more.
In Korea, the demand for complete underground installation of power distribution equipment installed on roads and green areas is increasing. In addition, KEPCO is making efforts to build a more reliable system for the underground distribution system. To meet these needs, this paper proposes the S-substation. In the S-substation, an RMU, a large power transformer, and an LV-Board (including ATCB and MCCB) are installed within the underground structure. This paper proposes three models to apply the S-substation to the underground distribution system. Power flow analysis is conducted for each model by simulating a variety of loads and DERs, and the frequency fluctuations are also examined under different distribution system events. An economic analysis is also conducted to select the optimal model. The economic analysis focuses on VOLL and construction costs. Based on power flow and economic analysis, one model is selected, and the underground distribution system that the model is applied is presented. Full article
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24 pages, 6604 KiB  
Article
Using Advanced Metering Infrastructure Data from MV/LV Substations to Minimize Reactive Energy Supply Cost to Final Consumers
by Jerzy Andruszkiewicz, J�zef Lorenc and Agnieszka Weychan
Energies 2024, 17(16), 4116; https://doi.org/10.3390/en17164116 - 19 Aug 2024
Viewed by 484
Abstract
This article presents an original methodology to determine the optimal level of reactive energy transmission to low-voltage consumers supplied from MV/LV substations that guarantees the lowest total costs of reactive energy transmission through the DSO network and its generation in receiving installations within [...] Read more.
This article presents an original methodology to determine the optimal level of reactive energy transmission to low-voltage consumers supplied from MV/LV substations that guarantees the lowest total costs of reactive energy transmission through the DSO network and its generation in receiving installations within the reactive power compensation process. The average value of the optimal factor tgφ to be maintained by customers depends on the efficiency of the network, the characteristics of the load, and the market costs of energy losses due to the transmission of reactive energy through the network that are covered by the DSO and the costs of reactive energy generation in receiving installations. The results presented for real MV/LV substations operating in the Polish distribution network demonstrate the application of annual measurements of active and reactive energy consumed and generated registered by AMI systems to calculate the optimal reactive power compensation level. They can be applied to verify the permissible levels of reactive energy compensation applied by the DSOs until now within the yearly tariffs for customers. Full article
(This article belongs to the Section F3: Power Electronics)
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24 pages, 2644 KiB  
Review
A Review of Voltage Control Studies on Low Voltage Distribution Networks Containing High Penetration Distributed Photovoltaics
by Xiaozhi Gao, Jiaqi Zhang, Huiqin Sun, Yongchun Liang, Leiyuan Wei, Caihong Yan and Yicong Xie
Energies 2024, 17(13), 3058; https://doi.org/10.3390/en17133058 - 21 Jun 2024
Cited by 2 | Viewed by 674
Abstract
Distributed photovoltaic (PV) in the distribution network accounted for an increasing proportion of the distribution network, and the power quality of the distribution network of the power quality problem is more and more significant. In this paper, the voltage regulation methods for low-voltage [...] Read more.
Distributed photovoltaic (PV) in the distribution network accounted for an increasing proportion of the distribution network, and the power quality of the distribution network of the power quality problem is more and more significant. In this paper, the voltage regulation methods for low-voltage distribution networks containing high-penetration PV are investigated. First, the working principles of the four voltage control methods are introduced: energy storage system configuration, regulating the reactive power output of PV inverters, restricting the active power output of PV, adjusting the switching positions of on-load regulator trap changer and distribution network reconfiguration, and then, in combination with the recent related research, the optimization of each method is compared horizontally with its respective concerns and characteristics. The optimization of each method is compared horizontally with the recent studies to find out the focus and characteristics of each method, and the shortcomings of each method are explored. Coordinated voltage control through multiple flexibility resources has become the mainstream voltage regulation scheme, and distribution network voltage regulation is considered from the perspective of flexibility resources. The three types of flexibility resources, namely, source, network, and storage, have been widely used in distribution network voltage regulation. Although load-side resources have become one of the main regulation resources of the new type of power system, the current study introduces less about the participation of load-side flexibility resources in voltage regulation of LV distribution networks and advancing the application of load-side resources in voltage regulation of LV distribution networks is the focus of future research. Then, the important role of load-side flexibility resources in voltage regulation is described in three parts, namely, the important role of load-side resources, the development trend, and the suggestions for promoting the coordination of source-network-load-storage flexibility resources, aiming to promote the application of load-side resources in voltage regulation in LV distribution networks, and the suggestions and programs are proposed for the technological challenges faced by voltage regulation. In the context of today’s new power system emphasizing the interaction of source, network, load, and storage, new technologies and methods for solving voltage problems in LV distribution networks are prospected, with a view to providing certain reference value for the actual operation and optimization of distribution network systems. Full article
(This article belongs to the Topic Distributed Generation and Storage in Power Systems)
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14 pages, 5223 KiB  
Article
Evaluation of Single-Photon Emission Computed Tomography Myocardial Perfusion Detection Capability through Physical Descriptors
by Dea Dundara Debeljuh, Roberta Matheoud, Ivan Pribanić, Marco Brambilla and Slaven Jurković
Appl. Sci. 2024, 14(12), 5283; https://doi.org/10.3390/app14125283 - 18 Jun 2024
Viewed by 793
Abstract
A comprehensive validation of data acquired by different myocardial perfusion imaging (MPI) systems was performed to evaluate contrast, self-attenuation properties, and perfusion detection capability. An anthropomorphic phantom with a myocardial insert and perfusion defect was used to simulate 99mTc-tetrofosmin distribution. Different MPI [...] Read more.
A comprehensive validation of data acquired by different myocardial perfusion imaging (MPI) systems was performed to evaluate contrast, self-attenuation properties, and perfusion detection capability. An anthropomorphic phantom with a myocardial insert and perfusion defect was used to simulate 99mTc-tetrofosmin distribution. Different MPI systems were evaluated: a SPECT system with iterative reconstruction algorithms and resolution recovery (IRR) with/without scatter correction (SPECT-IRR-SC and SPECT-IRR), and a cardio-centric IQ SPECT/CT system with IRR, with/without scatter and attenuation corrections (IQ-IRR-SC-AC and IQ-IRR). The image quality was assessed through physical descriptors: the contrast between the left ventricular (LV) wall and LV inner chamber (CLV/LVIC), intrinsic contrast (IC), and net contrast (NC). CLV/LVIC was found to be superior for IQ-IRR-SC-AC. The IC results showed non-uniformity of the signal intensity in the LV wall for the SPECT systems. The lowest IC values were obtained for IQ-IRR-SC-AC, except for septal position, where an underestimation of the signal intensity was revealed. The NC was found to be the highest for IQ-IRR-SC-AC and SPECT-IRR-SC. Additionally, for IQ-IRR-SC-AC, the NC increased in posterior and septal positions compared to IQ-IRR, enabling better perfusion detection capability over short-axis images. IQ-IRR showed performances comparable to SPECT-IRR. The characterization and evaluation perfusion detection capability of the MPI systems enabled the investigation of the systems’ performance and limitations. Full article
(This article belongs to the Special Issue Advances and Applications of Medical Imaging Physics)
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19 pages, 8171 KiB  
Article
Modeling and Simulation of Distribution Networks with High Renewable Penetration in Open-Source Software: QGIS and OpenDSS
by Ram�n E. De-Jes�s-Grull�n, Rafael Omar Batista Jorge, Abraham Espinal Serrata, Justin Eladio Bueno D�az, Juan Jos� Pichardo Est�vez and Nestor Francisco Guerrero-Rodr�guez
Energies 2024, 17(12), 2925; https://doi.org/10.3390/en17122925 - 14 Jun 2024
Cited by 1 | Viewed by 1212
Abstract
There are important challenges in modeling large electrical distribution circuits, especially with the presence of distributed renewable generation. Constructing simulations to assess the effect of the penetration of distributed generation on electrical distribution networks has become of great importance for Distribution Network Operators [...] Read more.
There are important challenges in modeling large electrical distribution circuits, especially with the presence of distributed renewable generation. Constructing simulations to assess the effect of the penetration of distributed generation on electrical distribution networks has become of great importance for Distribution Network Operators (DNOs). This paper proposes a simulation strategy based on open-source platforms and the integration of scripting tools for the rapid modeling of large-scale electrical distribution circuits with distributed renewable generation. The implementation is based on the adaptation of a tool called QGIS2OpenDSS, which creates OpenDSS distribution network models directly from an open-source geographic information system, QGIS. The plugin’s capabilities are demonstrated using a real distribution feeder with more than 60% penetration of renewable generation based on photovoltaic systems. These simulations are carried out using real data from a circuit provided by a DNO in the Dominican Republic, which is used to demonstrate how this approach provides a more accessible and flexible way to simulate and assess the effect of Distributed Energy Resources (DERs) in medium voltage (MV) and low voltage (LV) networks, enabling utilities to evaluate system performance and identify potential issues. The integration of this open-source tool within the DNO software stack enables users to apply it according to specific project needs, enhancing their capability to analyze and manage high DER penetration levels, aiding in better planning, operation, and decision-making processes related to renewable energy projects. Full article
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13 pages, 1228 KiB  
Article
Impact of Multiple Grid-Connected Solar PV Inverters on Harmonics in the High-Frequency Range
by Kasun Peiris, Sean Elphick, Jason David and Duane Robinson
Energies 2024, 17(11), 2639; https://doi.org/10.3390/en17112639 - 29 May 2024
Viewed by 958
Abstract
In recent years, integration of solar photovoltaic (PV) systems into distribution networks has been increasing rapidly, as it has become the most promising renewable energy source (RES) in the transition of power generation from centralised to decentralised systems. With the power electronic (PE) [...] Read more.
In recent years, integration of solar photovoltaic (PV) systems into distribution networks has been increasing rapidly, as it has become the most promising renewable energy source (RES) in the transition of power generation from centralised to decentralised systems. With the power electronic (PE) interfaces that use high-frequency internal switching, all renewable energy sources are considered to be harmonic emitters, especially near switching frequencies, i.e., above 2 kHz. This paper evaluates the behaviour of high-frequency harmonics in the 2–20 kHz range due to the parallel operation of multiple solar PV inverters connected to a low-voltage (LV) network. The circulation current component that flows within the installation due to the low impedance paths at higher frequencies is analysed. Summation of high-frequency harmonic currents is observed with phase diversity analysis. The circulating current component can become 14 times higher than the grid current component at higher frequencies. Full article
(This article belongs to the Section A: Sustainable Energy)
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40 pages, 6692 KiB  
Review
DER Control and Management Strategies for Distribution Networks: A Review of Current Practices and Future Directions
by Edward J. Smith, Duane A. Robinson and Sean Elphick
Energies 2024, 17(11), 2636; https://doi.org/10.3390/en17112636 - 29 May 2024
Viewed by 1273
Abstract
It is widely recognised that improving the visibility and controllability of distributed energy resources (DERs) within electricity distribution networks will have significant benefits, particularly for the management of low-voltage (LV) and medium-voltage (MV) networks. Much work within the electricity distribution industry is currently [...] Read more.
It is widely recognised that improving the visibility and controllability of distributed energy resources (DERs) within electricity distribution networks will have significant benefits, particularly for the management of low-voltage (LV) and medium-voltage (MV) networks. Much work within the electricity distribution industry is currently focused on improving the visibility of DERs on LV networks. From a control-theoretic perspective, this enables closing the loop between the DER and the control room and enables a shift towards utilising data-driven model-based control strategies for DERs. The result is a system-wide performance that is closer to the theoretical optimal. In the Australian context, several jurisdictions are trialling techniques such as dynamic operating envelopes to enhance DER hosting capacity, using IEEE 2030.5-based architectures, with the implementation of distributed energy resource management (DERMS) systems at the enterprise level still quite limited. While there is significant activity focused on DER behaviour and control techniques by way of inverter grid codes and standards, the core issue of interoperability with distribution management systems (DMSs), market operators or participants, electric vehicles (EVs) or other DERs is still a work in progress. Importantly, this is also an impediment to realising distributed architectures for DER control in the grid. The unique characteristics of Australian distribution networks highlights several challenging problems for DER control and management. The objective of this paper is to provide a broad overview of DER control and management strategies in the Australian context, with an application focus on DER control in distribution network management. Full article
(This article belongs to the Special Issue Modeling, Optimization, and Control in Smart Grids)
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30 pages, 3696 KiB  
Article
A Zonal Approach for Wide-Area Temporary Voltage Quality Assessment in a Smart Grid
by Miodrag Forcan, Aleksandar Simović, Srđan Jokić and Jovana Forcan
Energies 2024, 17(11), 2475; https://doi.org/10.3390/en17112475 - 22 May 2024
Cited by 1 | Viewed by 711
Abstract
Wide-area voltage quality assessment represents one of the mandatory objectives for distribution system operators in the development of advanced distribution management systems supporting smart grid requirements. This paper introduces a zonal approach for wide-area temporary voltage quality evaluation in a distribution network. The [...] Read more.
Wide-area voltage quality assessment represents one of the mandatory objectives for distribution system operators in the development of advanced distribution management systems supporting smart grid requirements. This paper introduces a zonal approach for wide-area temporary voltage quality evaluation in a distribution network. The concept of temporary voltage quality evaluation and assessment is recommended to incentivize active/online management of voltage quality issues. A decision support system based on simple deterministic rules is proposed for rating the voltage quality zones in a distribution network and making recommendations to the distribution system operator. Voltage RMS level, unbalance, and total harmonic distortion are considered voltage quality indices representing the inputs in the decision support system. Residential, commercial, and industrial load types are considered when setting the thresholds for voltage quality indices. The proposed zonal approach for the division of distribution networks in voltage quality zones is applied to the example of a typical European-type distribution network. The operation of a decision support system is tested using the developed distribution smart grid model. The following simulation case studies are conducted: loads with low power factors, manual voltage regulation at MV/LV transformers, unbalanced loads, integration of solar power plant, and nonlinear loads. The obtained simulation results reveal the benefits of the proposed voltage quality assessment approach. Cybersecurity challenges that may impact the proposed approach are addressed, including security vulnerabilities, data privacy, and resilience to cyber threats. Full article
(This article belongs to the Section A1: Smart Grids and Microgrids)
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12 pages, 1762 KiB  
Article
Decision Process for Identifying Appropriate Devices for Power Transfer between Voltage Levels in Distribution Grids
by Nassipkul Dyussembekova, Reiner Schütt, Ingmar Leiße and Bente Ralfs
Energies 2024, 17(9), 2158; https://doi.org/10.3390/en17092158 - 30 Apr 2024
Viewed by 659
Abstract
During the energy transition, new types of electrical equipment, especially power electronic devices, are proposed to increase the flexibility of electricity distribution grids. One type is the solid-state transformer (SST), which offers excellent possibilities to improve the voltage quality in electricity distribution grids [...] Read more.
During the energy transition, new types of electrical equipment, especially power electronic devices, are proposed to increase the flexibility of electricity distribution grids. One type is the solid-state transformer (SST), which offers excellent possibilities to improve the voltage quality in electricity distribution grids and integrate hybrid AC/DC grids. This paper compares SST to conventional copper-based power transformers (CPT) with and without an on-load tap changer (OLTC) and with additional downstream converters. For this purpose, a corresponding electricity distribution grid is set up in the power system analysis tool DIgSILENT PowerFactory 2022. A DC generator like a photovoltaic system, a DC load like an electric vehicle fast charging station, and an AC load are connected. Based on load flow simulations, the four power transformers are compared concerning voltage stability during a generator-based and a load-based scenario. The results of load flow simulations show that SSTs are most valuable when additional generators and loads are to be connected to the infrastructure, which would overload the existing grid equipment. The efficiency of using SSTs also depends on the parameters of the electrical grid, especially the lengths of the low-voltage (LV) lines. In addition, a flowchart-based decision process is proposed to support the decision-making process for the appropriate power transformer from an electrical perspective. Beyond these electrical properties, an evaluation matrix lists other relevant criteria like characteristics of the installation site, noise level, expected lifetime, and economic criteria that must be considered. Full article
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15 pages, 3402 KiB  
Article
Fluorescent α-Conotoxin [Q1G, ΔR14]LvIB Identifies the Distribution of α7 Nicotinic Acetylcholine Receptor in the Rat Brain
by Hongyu Shan, Nan Wang, Xinyu Gao, Zihan Wang, Jinpeng Yu, Dongting Zhangsun, Xiaopeng Zhu and Sulan Luo
Mar. Drugs 2024, 22(5), 200; https://doi.org/10.3390/md22050200 - 27 Apr 2024
Viewed by 1995
Abstract
α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized, and is closely related to [...] Read more.
α7 nicotinic acetylcholine receptors (nAChRs) are mainly distributed in the central nervous system (CNS), including the hippocampus, striatum, and cortex of the brain. The α7 nAChR has high Ca2+ permeability and can be quickly activated and desensitized, and is closely related to Alzheimer’s disease (AD), epilepsy, schizophrenia, lung cancer, Parkinson’s disease (PD), inflammation, and other diseases. α-conotoxins from marine cone snail venom are typically short, disulfide-rich neuropeptides targeting nAChRs and can distinguish various subtypes, providing vital pharmacological tools for the functional research of nAChRs. [Q1G, ΔR14]LvΙB is a rat α7 nAChRs selective antagonist, modified from α-conotoxin LvΙB. In this study, we utilized three types of fluorescein after N-Hydroxy succinimide (NHS) activation treatment: 6-TAMRA-SE, Cy3 NHS, and BODIPY-FL NHS, labeling the N-Terminal of [Q1G, ΔR14]LvΙB under weak alkaline conditions, obtaining three fluorescent analogs: LvIB-R, LvIB-C, and LvIB-B, respectively. The potency of [Q1G, ΔR14]LvΙB fluorescent analogs was evaluated at rat α7 nAChRs expressed in Xenopus laevis oocytes. Using a two-electrode voltage clamp (TEVC), the half-maximal inhibitory concentration (IC50) values of LvIB-R, LvIB-C, and LvIB-B were 643.3 nM, 298.0 nM, and 186.9 nM, respectively. The stability of cerebrospinal fluid analysis showed that after incubation for 12 h, the retention rates of the three fluorescent analogs were 52.2%, 22.1%, and 0%, respectively. [Q1G, ΔR14]LvΙB fluorescent analogs were applied to explore the distribution of α7 nAChRs in the hippocampus and striatum of rat brain tissue and it was found that Cy3- and BODIPY FL-labeled [Q1G, ΔR14]LvΙB exhibited better imaging characteristics than 6-TAMARA-. It was also found that α7 nAChRs are widely distributed in the cerebral cortex and cerebellar lobules. Taking into account potency, imaging, and stability, [Q1G, ΔR14]LvΙB -BODIPY FL is an ideal pharmacological tool to investigate the tissue distribution and function of α7 nAChRs. Our findings not only provide a foundation for the development of conotoxins as visual pharmacological probes, but also demonstrate the distribution of α7 nAChRs in the rat brain. Full article
(This article belongs to the Section Marine Toxins)
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14 pages, 4204 KiB  
Article
A New Approach for Single-Phase-to-Ground Fault Detection in Mid-Voltage Systems Using Low-Voltage Sensors
by Mingze Zhang and Xin Ai
Symmetry 2024, 16(4), 410; https://doi.org/10.3390/sym16040410 - 1 Apr 2024
Viewed by 1130
Abstract
Single-phase-to-ground fault in low-current grounding systems represents a serious public safety concern. Low-voltage (LV) sensors, with their growing maturity, can now monitor multiple points of the mid-voltage (MV) distribution network. This paper proposes a new method for identifying single-phase-to-ground line faults and locating [...] Read more.
Single-phase-to-ground fault in low-current grounding systems represents a serious public safety concern. Low-voltage (LV) sensors, with their growing maturity, can now monitor multiple points of the mid-voltage (MV) distribution network. This paper proposes a new method for identifying single-phase-to-ground line faults and locating them using LV sensors deployed on the LV side of distribution transformers. We analyze the characteristics of the negative-sequence signal on the LV side after a single-phase grounding fault occurs on the MV side. The negative-sequence current can distinguish between fault and non-fault lines. By setting the ratio coefficient of negative-sequence voltage and positive-sequence voltage, we can use multi-point collaborative calculation and comparison to determine the section of the fault point. We consider the unbalanced load on the LV side and the special case of a fault point on one end of the line. Through simulation of combined MV and LV distribution systems in MATLAB software and dynamic model experiments, we verify that the proposed method has good robustness and accuracy. Monitoring the status information of the MV distribution network through LV sensors has great potential in practical application and implementation for realizing the fault detection of low-current grounding systems. Full article
(This article belongs to the Section Engineering and Materials)
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