Version 1
: Received: 14 July 2023 / Approved: 17 July 2023 / Online: 17 July 2023 (10:58:52 CEST)
How to cite:
Silveira, S. D. S.; Moreira, V. M.; Peres, M. N. C.; Saavedra, L. P. J.; T�folo, L. P.; Andrade, F. A.; Ribeiro Domingos, T. A.; Da Silva Franco, C. C.; Mendes, C. M.; Malta, A.; Almeida, D. L.; Mathias, P. C. D. F. Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction. Preprints2023, 2023071077. https://doi.org/10.20944/preprints202307.1077.v1
Silveira, S. D. S.; Moreira, V. M.; Peres, M. N. C.; Saavedra, L. P. J.; T�folo, L. P.; Andrade, F. A.; Ribeiro Domingos, T. A.; Da Silva Franco, C. C.; Mendes, C. M.; Malta, A.; Almeida, D. L.; Mathias, P. C. D. F. Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction. Preprints 2023, 2023071077. https://doi.org/10.20944/preprints202307.1077.v1
Silveira, S. D. S.; Moreira, V. M.; Peres, M. N. C.; Saavedra, L. P. J.; T�folo, L. P.; Andrade, F. A.; Ribeiro Domingos, T. A.; Da Silva Franco, C. C.; Mendes, C. M.; Malta, A.; Almeida, D. L.; Mathias, P. C. D. F. Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction. Preprints2023, 2023071077. https://doi.org/10.20944/preprints202307.1077.v1
APA Style
Silveira, S. D. S., Moreira, V. M., Peres, M. N. C., Saavedra, L. P. J., T�folo, L. P., Andrade, F. A., Ribeiro Domingos, T. A., Da Silva Franco, C. C., Mendes, C. M., Malta, A., Almeida, D. L., & Mathias, P. C. D. F. (2023). Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction. Preprints. https://doi.org/10.20944/preprints202307.1077.v1
Chicago/Turabian Style
Silveira, S. D. S., Douglas Lopes Almeida and Paulo Cezar de Freitas Mathias. 2023 "Fructose-Induced Insulin Resistance in Adult Rats and Moderate-Intensity Training during Peri-Pubertal Period Improves Metabolic Dysfunction" Preprints. https://doi.org/10.20944/preprints202307.1077.v1
Abstract
The purpose of this study was to examine the impact of fructose consumption during the peri-pubertal period on the later onset of metabolic syndrome in rats. Additionally, the study sought to explore the potential of moderate-intensity physical training as a non-pharmacological approach to mitigate the fructose effects. Male rats, 30 days old, received 10% fructose, and were submitted to concomitant moderate-intensity training until 60 days old. They were divided into 4 groups: sedentary control (SC), sedentary fructose (SF), trained control (TC), and trained fructose (TF). Fructose consumption mainly affected adult animals, resulting in glucose intolerance, increased periepididymal fat, and increased total cholesterol, triglycerides, and insulin levels. Furthermore, these rats exhibited reduced sympathetic nerve activity. The moderate running led to a decrease in periepididymal and retroperitoneal adipose tissue, as well as a reduction in total cholesterol and improved glucose tolerance. Peri-pubertal rats that received combination treatments exhibited lower levels of glucose and insulin during an intraperitoneal glucose tolerance test. The results indicate that 10% fructose supplementation during peripuberty predisposes to metabolic syndrome in adulthood. However, simultaneous moderate-intensity exercise training attenuates these effects and induces positive changes in glycemic homeostasis, lipid metabolism, and autonomic nervous system activity.
Biology and Life Sciences, Endocrinology and Metabolism
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