Version 1
: Received: 13 June 2024 / Approved: 13 June 2024 / Online: 13 June 2024 (14:15:49 CEST)
Version 2
: Received: 15 July 2024 / Approved: 16 July 2024 / Online: 16 July 2024 (14:52:48 CEST)
Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N-(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained 76 % yield global using accessible starting materials and methodology in two reaction steps. Furthermore, we made docking studies of this compound on 3-TOP protein to explore its potential as an antidiabetic agent.
Chemistry and Materials Science, Medicinal Chemistry
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