N-(Benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)amino)butanamide

Hugo Pilotzi-Xahuentitla; Gabriela del Carmen Canche-Naal; Rolffy Ruben Ortiz-Andrade; Gabriel Navarrete-V�zquez; Emanuel Hern�ndez-N��ez

doi:10.20944/preprints202406.0924.v2

Preprint Short Note Version 2 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 13 June 2024 / Approved: 13 June 2024 / Online: 13 June 2024 (14:15:49 CEST)
Version 2 : Received: 15 July 2024 / Approved: 16 July 2024 / Online: 16 July 2024 (14:52:48 CEST)

Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N-(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained 76 % yield global using accessible starting materials and methodology in two reaction steps. Furthermore, we made docking studies of this compound on 3-TOP protein to explore its potential as an antidiabetic agent.

benzothiazole; benzoxazole; antidiabetic; molecular docking

Chemistry and Materials Science, Medicinal Chemistry

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N-(Benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)amino)butanamide

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