Prognostic Potential of CCT5 in Hepatocellular Carcinoma
Authors: 
Jun Wang, Jiahao Chen, Huimin Zhang, You Huang, Chao Shen, Xinghua LiaoAuthors Info & Claims
Jun Wang, Jiahao Chen, Huimin Zhang, You Huang, Chao Shen, Xinghua LiaoAuthors Info & ClaimsPages 147 - 154
Abstract
Chaperonin containing TCP1 subunit 5)CCT5( is a member of the companion protein containing the TCP1 complex (CCT), also known as the TCP1 loop complex (TRiC). The expression of CCT5 is abnormal in many cancers, but the biological role of CCT5 in hepatocellular carcinoma (LIHC) remains to be determined. We analyzed the expression of CCT5 using multiple gene expression databases. The genes co-expressed with CCT5 were identified using linkedonomics. The correlation between CCT5 and tumor immune infiltrates was studied by using tumor immune estimation resource (TIMER). CCT5 was found to be up-regulated in tumor tissues in multiple LIHC queues. High CCT5 expression was associated with overall survival (OS), relapse-free survival (RFS), progression-free survival (PFS) and disease-specific survival (DSS). Functional network analysis indicated that CCT5 was correlated with rectome Gene Formation Sets of tubulin folding intermediates by CCT/TRIC, ribonuclei complex protein biogenesis, rectome Gene Hsp90 chaoperone cycle for steroid hormone receptors (SHR). Significantly, CCT5 expression was positively correlated with the infiltration levels of B cell, CD4+T and CD8+T cells, macrophages, neutrophil, and dendritic cell. The expression of CCT5 is closely related to multiple immune markers in hepatocellular carcinoma. These findings suggest that CCT5 is associated with the prognosis and immunologic invasion of LIHC, and provide a basis for further study of the immunoregulatory role of CCT5 in LIHC.
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May 2021
293 pages
ISBN:9781450389655
DOI:10.1145/3473258
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Published: 11 December 2021
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ICBBT '21
ICBBT '21: 2021 13th International Conference on Bioinformatics and Biomedical Technology
May 21 - 23, 2021
Xi'an, China
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